Moderate Carbohydrate Intake Looks Best for Health

The debate rages on, low carb vs pretty much anything else at the moment.

The problem is getting through the noise to work out what’s going to be effective now, and for our longer-term health goals. Most of us are not prepared to give up one for the other.

The latest study to hit the headlines on this issue is not without its flaws, but it adds a rare long-term (25 year) insight.

Key Takeaways

• Moderate consumption of carbohydrate is associated with longest life expectancy
• Both low carb and high carb consumption is linked to lower life expectancy
• Plant based low carb diets are associated with lower risk of mortality than meat based low carb eating.

Eating carbohydrates in moderation seems to be optimal for health and longevity, suggests new research published in The Lancet Public Health journal.

The observational study of more than 15,400 people from the Atherosclerosis Risk in Communities Study (ARIC) in the USA found that:

• Diets low (less than 40% calories) and high (more than 70% calories) in carbohydrates were linked with an increase in mortality,
• Diets with a moderate of carbohydrate (50-55% of calories) had the lowest risk of mortality

The primary findings, confirmed in a meta-analysis of studies on carbohydrate intake including more than 432,000 people from over 20 countries, also suggest that not all low-carbohydrate diets appear equal.

• Eating more animal-based proteins and fats from foods like beef, lamb, pork, chicken and cheese instead of carbohydrate was associated with a greater risk of mortality.
• Eating more plant-based proteins and fats from foods such as vegetables, legumes, and nuts was linked to lower mortality.

"We need to look really carefully at what are the healthy compounds in diets that provide protection", says Dr Sara Seidelmann, Clinical and Research Fellow in Cardiovascular Medicine from Brigham and Women's Hospital, Boston, USA who led the research.

"Low-carb diets that replace carbohydrates with protein or fat are gaining widespread popularity as a health and weight loss strategy. However, our data suggests that animal-based low carbohydrate diets, which are prevalent in North America and Europe, might be associated with shorter overall life span and should be discouraged.

Instead, if one chooses to follow a low carbohydrate diet, then exchanging carbohydrates for more plant-based fats and proteins might actually promote healthy ageing in the long term."

The Study Researchers began by studying 15,428 adults aged 45-64 years from diverse socioeconomic backgrounds enrolled in the ARIC cohort between 1987 and 1989.

At the start of the study and again 6 years later, participants completed a dietary questionnaire on the types of food and drinks they consumed, what portion size and how often.

Researchers used this data to estimate the cumulative average of calories partcipants derived from carbohydrates, fats, and protein. The researchers assessed the association between overall carbohydrate intake and all cause-mortality after adjusting for age, sex, race, total energy intake, education, exercise, income level, smoking, and diabetes.

During a median follow-up of 25 years, 6283 people died.

Results showed a U-shape association between overall carbohydrate intake and life expectancy.

Low (less than 40% of calories) and high (more than 70%) intake of carbohydrates associated with a higher risk of mortality compared with moderate intake (50-55% of calories).

The researchers estimated that from age 50, the average life expectancy was an additional: 33 years for those with moderate carbohydrate intake 32 years for those with high carbohydrate consumption

The authors highlight that since diets were only measured at the start of the trial and 6 years later, dietary patterns could change over 25 years, which might make the reported effect of carbohydrate consumption on lifespan less certain.

In the next step of the study, the authors performed a meta-analysis of data from eight prospective cohorts (including ARIC) involving data from 432,179 people in North American, European, and Asian countries.

This revealed similar trends, with participants whose overall diets were high and low in carbohydrates having a shorter life expectancy than those with moderate consumption.

Seidelmann explains, "A midrange of carbohydrate intake might be considered moderate in North America and Europe where average consumption is about 50% but low in other regions, such as Asia, where the average diet consists of over 60% carbohydrates."

In further analyses examining whether the source of proteins and fats favoured in low-carbohydrate diets was associated with length of life, researchers found that Replacing carbohydrates with protein and fat from animal sources was associated with a higher risk of mortality than moderate carbohydrate intake. In contrast, replacing carbohydrates with plant-based foods was linked to a lower risk of mortality.

"These findings bring together several strands that have been controversial. Too much and too little carbohydrate can be harmful but what counts most is the type of fat, protein, and carbohydrate," says Walter Willett, Professor of Epidemiology and Nutrition at Harvard T. H. Chan School of Public Health and co-author of the study.

The findings show observational associations rather than cause and effect.

Considering evidence from other studies, the authors speculate that:

• Western-type diets that heavily restrict carbohydrates often result in lower intake of vegetables, fruit, and grains and lead to greater consumption of animal proteins and fats. (Some of which have been implicated in stimulating inflammatory pathways, biological ageing, and oxidative stress--and could be a contributing factor to the increased risk of mortality.)
• Whilst high carbohydrate diets (common in Asian and less economically advantaged nations) tend to be high in refined carbohydrates such as white rice, may also contribute to a chronically high glycaemic load and worse metabolic outcomes.

"This work provides the most comprehensive study of carbohydrate intake that has been done to date, and helps us better understand the relationship between the specific components of diet and long term health", says Dr Scott Solomon, The Edward D Frohlich Distinguished Chair at Brigham and Women's Hospital and Professor of Medicine at Harvard Medical School, and senior author on the paper.

"While a randomized trial has not been performed to compare the longer term effects of different types of low carbohydrate diets, these data suggest that shifting towards a more plant-based consumption is likely to help attenuate major morbid disease."

The authors note some limitations including:

• Dietary patterns were based on self-reported data, which might not accurately represent participants' food consumption.
• Their conclusions about animal-based sources of fat and protein might have less generalisability to Asian populations which tend to have diets high in carbohydrates, but often consume fish rather than meat.
• Given the relatively small number of individuals following plant-based low-carb diets, further research is needed.

Writing in a linked Comment, Dr Andrew Mente and Dr Salim Yusuf from McMaster University, Hamilton, Canada said:

Such differences in risk associated with extreme differences in intake of a nutrient are plausible, but observational studies cannot completely exclude residual confounders when the apparent differences are so modest.

Based on first principles, a U-shaped association is logical between most essential nutrients versus health outcomes. Essential nutrients should be consumed above a minimal level to avoid deficiency and below a maximal level to avoid toxicity.

This approach maintains physiological processes and health (ie, a so-called sweet spot).

Although carbohydrates are technically not an essential nutrient (unlike protein and fats), a certain amount is probably required to meet short-term energy demands during physical activity and to maintain fat and protein intakes within their respective sweet spots.

On the basis of these principles, moderate intake of carbohydrate (eg, roughly 50% of energy) is likely to be more appropriate for the general population than are very low or very high intakes."

All wlr diet plans are nutritionally balanced 50-55% carbs, 15-20% protein, 25-30% fat